Welcome to the Website of Taki Laboratory


The update of this English homepage is not as frequent as that of Japanese one. For the latest information, please kindly use Google translate (https://translate.google.com/) and just enter this URL (http://tkl.pc.uec.ac.jp/). Our goal is to reduce drugs. To reduce the amount/frequency/dose, we are inventing fundamental technologies on targeted drugs, such as developing covalent biologics. Also, we aim to educate students by doing such tough researches that meet the quality of world-wide standards. We strongly promote lab members to take their own risks to conquer the very first findings which have never ever attained.


Targeted Covalent Inhibitors (TCIs), such as aspirin (Bufferin), have a long history of more than 120 years, and most of them are small molecules. We have focused on biomolecular targeted covalent inhibitors (bioTCIs), which are more molecular-specifically targeted than small-molecular TCIs. We have specialized in "middle-sized bioTCIs" (midTCIs), which are particularly easy to produce. We have achieved:
(1) Combinatorial screening of peptide-type TCIs
(2) Transformation of DNA aptamers into TCIs
We have published a review of the historical background and the latest trends of bioTCI, including the above as an open access article.
bioTCIs: Middle-to-Macro Biomolecular Targeted Covalent Inhibitors Possessing Both Semi-Permanent Drug Action and Stringent Target Specificity as Potential Antibody Replacements
by Jay Yang, Yudai Tabuchi, Riku Katsuki, and Masumi Taki
Int. J. Mol. Sci. 2023, 24(4), 3525;
In Topical Collection "State-of-the-Art Molecular Immunology in Japan"
We would like to thank the guest editors of the above Special Issue for inviting us, the two anonymous reviewers, and all the Editors of the Journal who were involved in the composition of this issue.
I gave an invited talk at the JAIST Biofunctional Biomedical Engineering Research Area Seminar.
Title: Medium Molecular Covalent Drugs
We thank Profs. Hohsaka & Watanabe of JAIST for hosting our presentation.
An article about mechano-chemistry/biology field is in press: M. Taki*, T. Yamashita, K. Yatabe, and V. Vogel*, Mechano-chromic protein-polymer hybrid hydrogel to visualize mechanical strain, Soft Matter, in press (2019); Prof. Taki (@UEC) & Prof. Yamashita (@Univ. Keio) equally contributed to the work.
Hirasawa's work about middle molecules-Fc fusion made by the NEXT-A reaction was selected as a front cover article of Bioconjugate Chemistry (September). This work was also featured in UEC e-Bulletin English version: http://www.ru.uec.ac.jp/e-bulletin/research-highlights/2019/convenient-synthesis-of-biopharmaceutic-fc-conjugates.html
2019.09.17 Prof. Taki performed a seminar at ETH Zurich (Switzerland) entitled:Targeted binders from combinatorial library for medicinal / diagnostic uses.
Yudai & Prof. Taki poster presentations entitled: Yudai Tabuchi, Masumi Taki, Fluorescent "keep-on" type pharmacophore obtained from dynamic combinatorial library of Schiff bases at International Symposium on Dyes & Pigments (Seville, Spain).
Prof. Taki performed a seminar at Nihon University.
Kazuki poster presentations entitled: Kazuki Yatabe, Masaru Hisada, Yudai Tabuchi & Masumi Taki, Novel photo-crosslinking caged fluorophore as peptide cysteine modifier: binding-site determination of the targeted peptide binder at 27th FAOBMB & 44th MSBMB Conference (Kuala Lumpur, Malaysia).
An article is in press:
Hirasawa S*, Kitahara Y, Okamatsu Y, Fujii T, Nakayama A, Ueno S, Ijichi C, Futaki F, Nakata K, and Taki M*,
Facile and Efficient Chemoenzymatic Semi-Synthesis of Fc-Fusion Compounds for Half-Life Extension of Pharmaceutical Components, Bioconj. Chem., 2019, in press; doi: 10.1021/acs.bioconjchem.9b00235.

Our website has been renewed. Ichinose(B4) designed the logotype.
Hirasawa performed poster presentations entitled:
A7: S. Hirasawa, Y. Kitahara, Y. Okamatsu, A. Nakayama, S. Ueno, M. Taki, Half-Life Extension Technology Using Semi-Synthetic Fc-Fusions @ Boston, Massachusetts, USA.
Y.Tabuchi & K.Yatabe got awarded for their research activities.

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