Welcome to the Website of Taki Laboratory
Message
Our goal is to reduce drugs. To reduce the
amount/frequency/dose, we are inventing fundamental technologies on targeted drugs, such
as developing combinatorial screening of BIOmolecular Targeted Covalent Inhibitors
(bioTCIs). Also, we aim to educate students by doing such tough researches that meet the
quality of world-wide standards. We strongly promote lab members to take their own risks to
conquer the very first findings which have never ever attained
News
- 2024.12.13
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We have developed the ARCaDia method, which applies the ARC method (established in 2021 for Affinity/Reactivity Co-selection) to the discovery of DNA aptamer-type covalent binders. Specifically, this method, combined with bioinformatics techniques, enables the rapid determination of DNA sequences that form covalent bonds exclusively with target proteins in just two days of experimentation.
Masumi Taki*, Masayasu Kuwahara, Chaohui Li, Naoko Tomoda, Naoyuki Miyashita (Visiting Associate Professor, UEC), Tetsuo Kan (Professor, UEC Graduate School of Informatics and Engineering), Jay Yang* (Visiting Professor, UEC),
ARCaDia: single-round screening of a DNA-type targeted covalent binder possessing a latent warhead, Chem. Commun., 2024, 60, 14964; DOI: 10.1039/D4CC04594G.
We would like to express our gratitude to the anonymous reviewers and to Professor Hamachi and the Editors for selecting our work as a Back-Cover Article. This paper is open access and can be freely accessed via the following link. We also extend our thanks to the University of Electro-Communications (UEC) for funding the high open-access publication fees.
https://pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc04594g
Side Note: It took a full four years from conception and initial experiments to completion, and we nearly abandoned the project in January of this year due to the lack of results. The cover artwork is inspired by the Hanafuda card game?particularly the scenario where a bold first move earns the sake cup in the chrysanthemum card suite, symbolizing our achievement of a “first-round (fastest/shortest)” success. Naturally, we aim to “Koi-Koi” (continue playing) and achieve the highest score of Goko. The decision not to use the cherry blossom card reflects the project's completion in September (linked to the boar card). Subtly, the wild geese card, representing the aptamer library, has been replaced with cormorants,inspired by Japan’s traditional cormorant fishing (an idea from co-corresponding author Prof. Yang). We are grateful to the team at Science Graphics for their help in realizing this concept
